Verification-Guided Retrosynthesis: Reaction Feedback and Evidence Timing
arXiv:2610.38245v1 Announce Type: new Abstract: Retrosynthesis planning seeks synthesis routes from purchasable starting materials to a target molecule. Search over predicted reactions can connect a target to available materials, yet an infeasible reaction can invalidate the resulting route. Evaluating route quality only after search has finished cannot correct errors made during search. We introduce Verification-Guided Reflow (VGR), incorporating reaction verification as a decision action in A…